Osteoarthritis, an inflammatory, degenerative disease of joints mostly affects weight bearing joints in old age. Most commonly involved joint is knee. As long term treatment is required for this chronic and debilitating disease; people are now seeking use of herbal medicines for effective relieve of the symptoms. This is on account of easy availability, low cost and fewer adverse effects. The team has evaluated and compared the clinical efficacy of Naproxen-ginger group with Naproxen and Diacerein-ginger group with Diacerein including the adverse effects of administered regimens.